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In issuing its test procedure, DOE has resolved or addressed the various commenter issues concerning testing

These methods are not easily comparable: they differ in sample sizes, time periods covered, and scientific rigor, and they yield different estimates and have different sources of error

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Additionally, studies have found 505 hazardous chemicals in flavoured vapes, including 127 which are acutely toxic, and 153 health hazards, which are formed as a result of vaping